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Funded Project Details - FY2021




Project Number:

I01BX002425-05A1
Title: DNase-Targeted Mitigation of Acute Kidney Injury Due to Rhabdomyolysis
Principal Investigator:

Alexei G. Basnakian

Location: Little Rock, AR
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: October 2019 - September 2023
FY 2021 Funding Amount: $263,535
Total Award Amount
(all years):
$1,238,340
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

The United States Armed Forces are routinely exposed to hazardous weapons, pathogens, environmental toxins and, later, medical countermeasures with long-term health effects. The kidney is affected by many toxins metabolized in the body that it excretes, including products of rhabdomyolysis (skeletal muscle degradation), hemolysis, drugs, and exogenous toxins. Many of these compounds cause acute kidney injury (AKI) by producing reactive oxygen species (ROS), which activate apoptotic endonucleases...



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