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Funded Project Details - FY2021

Project Number:

Title: Optogenetics: A tool to probe mechanism and an agent to block TBI-induced epileptogenesis.
Principal Investigator:

John T. Slevin

Location: Lexington, KY
Congressional District Code: 6
Research Service: Biomedical Laboratory R&D
Project Period: April 2019 - March 2023
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Over two million people are treated medically each year in the United States after sustaining a traumatic brain injury (TBI). Posttraumatic epilepsy (PTE) develops in up to 39% of patients with moderate to severe, non-penetrating TBI. As with other acquired epilepsies, spontaneous recurrent seizures associated with PTE develop with a latency (>1 week and up to many years) after the initial injury. This seizure-free period after TBI represents the period of epileptogenesis, during which the brain...

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