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Funded Project Details - FY2021




Project Number:

I01BX003643-01A2
Title: TBI-induced exosome release accelerates Alzheimer's disease pathology
Principal Investigator:

Erhard Bieberich

Location: Lexington, KY
Congressional District Code: 6
Research Service: Biomedical Laboratory R&D
Project Period: October 2019 - September 2023
FY 2021 Funding Amount: $232,064
Total Award Amount
(all years):
$1,081,949
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Alzheimer's disease (AD) is characterized by build-up of Aβ peptides forming amyloid plaques and hyper- phosphorylation of tau protein forming neurofibrillary tangles, a two-fold protein aggregation process leading to progressive neurodegeneration and cognitive decline. Epidemiological studies show that the risk of developing AD is 4-fold higher in persons who have experienced head trauma or traumatic brain injury (TBI), which is prevalent in Veterans returning from active combat. Reasons for th...



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