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Funded Project Details - FY2021

Project Number:

Title: Identification of the Molecular Mechanisms Linking Alzheimer's Disease, PERK, and Mild Repetitive Head Injury
Principal Investigator:

Jose Abisambra

Location: Gainesville, FL
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: October 2020 - February 2025
FY 2021 Funding Amount: $128,359
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


This study will establish the molecular mechanism linking mild repetitive traumatic brain injury (mrTBI) and onset of tau pathology that is associated with Alzheimer's disease (AD). Our preliminary data suggest that endoplasmic reticulum stress is a notable and long-lasting cascade that is activated by injury. ER stress acti- vates a protein called PERK, which is responsible for initiating protective pathways that help restore ER func- tion. However, long-term activation of PERK leads to cell de...

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