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Project Number: | I01BX004563-01A1 |
| Title: | Identification of the Molecular Mechanisms Linking Alzheimer's Disease, PERK, and Mild Repetitive Head Injury |
| Principal Investigator: | Jose Abisambra |
| Location: | Gainesville, FL |
| Congressional District Code: | 3 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2020 - February 2025 |
| FY 2021 Funding Amount: | $128,359 |
| Total Award Amount (all years): |
$1,002,789 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: This study will establish the molecular mechanism linking mild repetitive traumatic brain injury (mrTBI) and onset of tau pathology that is associated with Alzheimer's disease (AD). Our preliminary data suggest that endoplasmic reticulum stress is a notable and long-lasting cascade that is activated by injury. ER stress acti- vates a protein called PERK, which is responsible for initiating protective pathways that help restore ER func- tion. However, long-term activation of PERK leads to cell de... |