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Funded Project Details - FY2021

Project Number:

Title: p75NTR ligands for ALS therapy
Principal Investigator:

Stephen M. Massa

Location: San Francisco, CA
Congressional District Code: 12
Research Service: Biomedical Laboratory R&D
Project Period: July 2019 - June 2021
FY 2021 Funding Amount: $56,250
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Amyotrophic lateral sclerosis (ALS) is a progressive, disabling and ultimately fatal neuromuscular disease which has increased incidence in veterans and upon which currently available therapies have only nominal effects. The overall goal of this proposal is to determine whether a small molecule modulator of the p75 neurotrophin receptor (p75NTR) will inhibit progression of pathology and improve outcomes in ALS. Impaired neurotrophin-mediated signaling and activation of p75NTR-associated death me...

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