Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government

Office of Research & Development

print icon sign up for VA Research updates

Funded Project Details - FY2021




Project Number:

I01BX004313-01A1
Title: CTBI: Tauopathy in Mice and Human: Effects of Open-Field Low-Intensity Blast on Brain Ultrastructure and Outcomes in Mild Traumatic Brain Injury
Principal Investigator:

Zezong Gu

Location: Columbia, MO
Congressional District Code: 4
Research Service: Biomedical Laboratory R&D
Project Period: October 2019 - September 2023
FY 2021 Funding Amount: $308,584
Total Award Amount
(all years):
$1,370,674
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Project Summery Overall Research Strategy: Traumatic brain injury (TBI) from open-field blast or repetitive mild head impact to human tau transgenic mice will induce Alzheimer-relevant, tau-dependent pathology, that can be rescued by suppression of tau expression or tau aggregation inhibitors. Blast-induced tau-related pathological changes will be analyzed in brains from veterans and mice exposed to blast, and biomarkers for TBI, chronic traumatic en- cephalopathy (CTE) and Alzheimer-pathology w...



Questions about the R&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.