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Funded Project Details - FY2021

Project Number:

Title: Identifying molecular markers that predict relapse after therapy discontinuation inchronic myeloid leukemia.
Principal Investigator:

Elizabeth A. Eklund

Location: Chicago, IL
Congressional District Code: 7
Research Service: Clinical Science R&D
Project Period: April 2019 - March 2023
FY 2021 Funding Amount: $165,000
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Clinical outcomes in chronic myeloid leukemia (CML) were revolutionized by development of imatinib (IM) and later generation tyrosine kinase inhibitors (TKIs) that target the Bcr-abl oncogene. Currently, ~55% patients with newly diagnosed CML achieve a major molecular response to TKI treatment (MMR) and 17% a complete molecular response (CMR). Because CML patients survive many years, there is interest in identifying those who can discontinue treatment. This interest is encouraged by the 30% inci...

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