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Funded Project Details - FY2021




Project Number:

I01CX001933-01
Title: Cross-comparison of patient-derived xenografts and derivative organoids and cell lines for translational research in hepatocellular carcinoma
Principal Investigator:

David E. Kaplan

Location: Philadelphia, PA
Congressional District Code: 3
Research Service: Clinical Science R&D
Project Period: January 2020 - December 2023
FY 2021 Funding Amount: $165,000
Total Award Amount
(all years):
$699,939
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

PROJECT SUMMARY Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide with more than 745,000 fatalities in 2012 alone. The majority of patients with HCC present with unresectable disease at diagnosis and a life expectancy of less than 20 months, with only 15% of these patients surviving more than one year after diagnosis. This dismal prognosis underscores the limited therapeutic options for these patients. HCC is a notoriously chemoresistant malignancy and...



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