Funded Project Details - FY2021
|Title:|| Chromatin Regulation by Mammalian SIRT7 in Aging and Disease|
Katrin F. Chua
||Palo Alto, CA
|Congressional District Code:
||Biomedical Laboratory R&D
|| October 2019 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
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Aging is the single greatest risk factor for many chronic diseases and thus is a major contributor to morbidity in the VA population. Our broad research goal is to understand how chromatin regulatory mechanisms influence nuclear and epigenetic programs, and how de-regulation of these mechanisms contributes to aging and disease. The work proposed here will focus on elucidating the functions of SIRT7, a chromatin regulatory enzyme in the Sirtuin family of aging-regulatory factors. Inactivation of...
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