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Project Number: | I01CX001971-01A2 |
| Title: | Immune control of chronic viral infection in solid organ transplantation |
| Principal Investigator: | Jonathan S. Maltzman |
| Location: | Palo Alto, CA |
| Congressional District Code: | 18 |
| Research Service: | Clinical Science R&D |
| Project Period: | October 2019 - September 2023 |
| FY 2021 Funding Amount: | $155,000 |
| Total Award Amount (all years): |
$710,000 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Immunosuppression required for lifesaving solid organ transplantation induces significant morbidity including increased recurrence of latent viral infection in transplant recipients. Approximately 60-70% of adults in the United States are latently infected with Cytomegalovirus (CMV). Control of latent CMV is thought to depend on a constantly active immune response, specifically by memory T lymphocytes. In those with a normal immune system, control of latent CMV is a constant “battle” and results... |