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Funded Project Details - FY2021

Project Number:

Title: BLR&D Research Career Scientist Award
Principal Investigator:

Gianfranco D. Alpini

Location: Indianapolis, IN
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: April 2019 - March 2026
FY 2021 Funding Amount: $138,000
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Bile duct epithelial cells (i.e., cholangiocytes) are the target cells in cholangiopathies such as primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and cholangiocarcinoma (CCA), which are diseases characterized by the damage, proliferation and neoplastic transformation of cholangiocytes. These cholestatic liver diseases (characterized by coordinated proliferation/damage of biliary epithelial cells) along with other cholangiopathies represent a major clinical challenge due...

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