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Funded Project Details - FY2021

Project Number:

Title: Effects of 12-weeks of High-intensity Resistance Aerobic Circuit Exercise Training on Epigenetic Aging and Inflammation in Older HIV-infected Veterans
Principal Investigator:

Kris Ann Oursler

Location: Salem, VA
Congressional District Code: 9
Research Service: Rehabilitation R&D
Project Period: October 2019 - September 2023
FY 2021 Funding Amount: $291,118
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The Veterans Health Administration (VHA) is the largest U.S. HIV health provider with 64% of these Veterans 50+ years of age. HIV infection in the setting of antiretroviral therapy represents a chronic disease with an advanced aging phenotype manifested as increased cardiovascular disease, sarcopenia, and frailty, primarily driven by systemic inflammation. We found a 42% reduction in VO2peak in older HIV+ adults that significantly improved with high-intensity aerobic (AEX) and resistance trainin...

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