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Funded Project Details - FY2021

Project Number:

Title: Mechanisms of Liver Injury
Principal Investigator:

Chandrashekhar R. Gandhi

Location: Cincinnati, OH
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: January 2020 - December 2023
FY 2021 Funding Amount: $272,375
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Acute liver failure (ALF) is a devastating condition with high mortality (60-80%), and liver transplantation is the only life-saving option for ALF due to the lack of early diagnostic indicator(s) and effective pharmacologic treatment. Incidence of drug-induced (acetaminophen [APAP] being most common) hepatotoxicity is very high in general and in particular VA populations, and accounts for about 15% of the liver transplants. Therefore, precise knowledge of the mechanisms and diagnostic indicator...

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