Funded Project Details - FY2021
|Title:|| Mechanisms of Liver Injury|
Chandrashekhar R. Gandhi
|Congressional District Code:
||Biomedical Laboratory R&D
|| January 2020 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
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Acute liver failure (ALF) is a devastating condition with high mortality (60-80%), and liver transplantation is the only life-saving option for ALF due to the lack of early diagnostic indicator(s) and effective pharmacologic treatment. Incidence of drug-induced (acetaminophen [APAP] being most common) hepatotoxicity is very high in general and in particular VA populations, and accounts for about 15% of the liver transplants. Therefore, precise knowledge of the mechanisms and diagnostic indicator...
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