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Funded Project Details - FY2021




Project Number:

I01BX004632-01A1
Title: The roles of the necroptotic and excitotoxic pathways in diisopropyl fluorophosphate-induced neuronal necrosis
Principal Investigator:

Denson G. Fujikawa

Location: Sepulveda, CA
Congressional District Code: 29
Research Service: Biomedical Laboratory R&D
Project Period: April 2020 - March 2024
FY 2021 Funding Amount: $156,316
Total Award Amount
(all years):
$707,776
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Our objective in this project is to determine the destructive seizure-inducing effects of the systemically administered organophosphate diisopropyl fluorophosphate (DFP) on rat brain, and to determine the roles of the necroptotic and exitotoxic pathways of programmed necrosis in DFP- induced neuronal necrosis. For Specific Aim 1 we will determine the time course and degree of neuronal necrosis (using the hematoxylin and eosin [H & E] stain) and nuclear translocation of receptor-interacting prote...



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