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Funded Project Details - FY2021




Project Number:

I01BX002891-05
Title: SPAK inhibitor ZT-1a for ischemic stroke therapy
Principal Investigator:

Dandan Sun

Location: Pittsburgh, PA
Congressional District Code: 18
Research Service: Biomedical Laboratory R&D
Project Period: October 2020 - September 2024
FY 2021 Funding Amount: $235,677
Total Award Amount
(all years):
$738,877
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

PROJECT ABSTRACT Stroke remains as the 5th leading cause of death and long-term adult disability in the USA because only ~15% patients can benefit from current standard therapies ( tissue plasminogen activator and endovascular recanalization) due to their short therapeutic windows. Therefore, identification of novel stroke therapeutic targets for neuroprotective drugs remains to be an unmet urgent need. Hypertension is the most significant risk factor for stroke epidemics and angiotensin II (Ang...



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