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Project Number: | I01BX002891-05 |
| Title: | SPAK inhibitor ZT-1a for ischemic stroke therapy |
| Principal Investigator: | Dandan Sun |
| Location: | Pittsburgh, PA |
| Congressional District Code: | 18 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2020 - September 2024 |
| FY 2021 Funding Amount: | $235,677 |
| Total Award Amount (all years): |
$738,877 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: PROJECT ABSTRACT Stroke remains as the 5th leading cause of death and long-term adult disability in the USA because only ~15% patients can benefit from current standard therapies ( tissue plasminogen activator and endovascular recanalization) due to their short therapeutic windows. Therefore, identification of novel stroke therapeutic targets for neuroprotective drugs remains to be an unmet urgent need. Hypertension is the most significant risk factor for stroke epidemics and angiotensin II (Ang... |