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Funded Project Details - FY2021

Project Number:

Title: Regulatory Role of ILC2 in Acute Lung Injury in Sepsis
Principal Investigator:

Jie Fan

Location: Pittsburgh, PA
Congressional District Code: 18
Research Service: Biomedical Laboratory R&D
Project Period: April 2021 - March 2025
FY 2021 Funding Amount: $27,343
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Severe sepsis complicated with multiple organ dysfunction syndrome (MODS) is a leading cause of death in ICU. Acute lung injury (ALI) is an important component of MODS and often serves as a direct cause of death. Nonetheless, few effective therapeutic targets for ALI have been identified. Our long-term goal is to determine the mechanisms by which sepsis promote ALI, thereby potentially identifying novel targets for prophylactic intervention. Innate lymphoid cells (ILCs), a new member of the lymp...

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