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Funded Project Details - FY2021

Project Number:

Title: Regulation of glucose homeostasis via the molecular clock machinery and the hepatic vagus nerve after Roux-en-Y gastric bypass
Principal Investigator:

Mohamad Mokadem

Location: Iowa City, IA
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: January 2020 - December 2023
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


This application describes a structured research plan targeted to explore the role of the molecular “clock” – which is responsible for maintaining endogenous circadian rhythm - in the mechanism of glucose regulation after gastric bypass. It is estimated that ~ 30 million Americans have diabetes (mainly type 2) which has been tightly associated with insulin resistance and obesity. Furthermore, 1 in every 3 Americans is currently obese and by the year 2020 it’s estimated that ~ 75% will be either...

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