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Funded Project Details - FY2021

Project Number:

Title: Understanding the multifaceted functions of MG53 in heart failure pathogenesis
Principal Investigator:

Long-Sheng Song

Location: Iowa City, IA
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: April 2020 - March 2024
FY 2021 Funding Amount: $229,510
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Heart failure is the most common health concern for aging veterans. At the cellular and molecular level, heart failure is the result of cardiomyocyte contractile failure due to impairment of cardiac excitation-contraction (E-C) coupling process. E-C coupling is the central mechanism governing cardiomyocyte contraction. One critical structural component of E–C coupling is the myocyte transverse (T)-tubule system. T-tubules are orderly invaginations of surface membrane into the cell interior and a...

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