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Funded Project Details - FY2021

Project Number:

Title: The role of nicotinamide mononucleotide dependent mitochondrial reactive oxygen species generation in acute brain injury
Principal Investigator:

Tibor Kristian

Location: Baltimore, MD
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: April 2020 - March 2024
FY 2021 Funding Amount: $310,938
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Impairments in mitochondrial functions have been frequently implicated in ischemic brain injury associated with cardiac arrest or stroke. However, the extent to which mitochondrial dysfunction contributes to neurodegeneration is unknown; and the mechanisms leading to mitochondrial failure are not well understood. Recently, it was suggested that an imbalance in mitochondrial fission/fusion dynamics can lead to neurodegeneration and brain damage. Furthermore, overactivation of nicotinamide adenine...

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