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Funded Project Details - FY2021

Project Number:

Title: Combinatorial Targeting of the Cell Cycle and Key Interacting Pathways in Mesothelioma
Principal Investigator:

Mark Klein

Location: Minneapolis, MN
Congressional District Code: 5
Research Service: Biomedical Laboratory R&D
Project Period: April 2020 - March 2024
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The Problem: Mesothelioma is a devastating cancer where the majority of patients will die from their disease. The last significant advance in chemotherapy for mesothelioma was pemetrexed, which was approved by the FDA in 2004. The vast majority of mesothelioma tumors have defects in the cell cycle. Low expression of the CDK4/CDK6 inhibitor p16INK4a has been demonstrated in multiple basic and clinical studies of mesothelioma. A phase III study reported a significant increase in survival in breast...

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