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Funded Project Details - FY2021

Project Number:

Title: Physiologic regulation of soluble Klotho levels by systemic acid/base status
Principal Investigator:

R. Tyler Miller

Location: Dallas, TX
Congressional District Code: 30
Research Service: Biomedical Laboratory R&D
Project Period: April 2020 - March 2024
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Chronic kidney disease (CKD) frequently progresses to end-stage renal disease accompanied by complications including cardiac hypertrophy, accelerated vascular disease, ectopic calcification, endothelial dysfunction, osteodystrophy, sarcopenia, skin atrophy, and renal fibrosis. Factors including hypertension, volume-overload, acidosis, chronic low-grade inflammation, disordered Ca and PO4 metabolism, elevated PTH and FGF23 levels, and reduced circulating ´üíKlotho (sKlotho) levels are associated wi...

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