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Funded Project Details - FY2021

Project Number:

Title: Novel sterile inflammatory pathways in alcoholic hepatitis
Principal Investigator:

Natalie Torok

Location: Palo Alto, CA
Congressional District Code: 18
Research Service: Biomedical Laboratory R&D
Project Period: January 2020 - December 2023
FY 2021 Funding Amount: $158,050
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Alcoholic hepatitis (AH) affects disproportionally high numbers of veterans, and has a mortality rate that has not changed substantially over the last decade. As AH pathogenesis has distinct features and is characterized by very severe hepatocyte injury, sterile inflammation and neutrophil recruitment; our goal is to identify molecular targets that have significant roles in these processes. We found that dysregulation of the Src homology 2 domain containing (Shc) collagen-related proteins play i...

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