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Funded Project Details - FY2021




Project Number:

I01BX004584-01A1
Title: Unique Non-Saccharide Mimetics of Sulfated Glycosaminoglycan Target Colon Cancer Stem Cells
Principal Investigator:

Bhaumik Patel

Location: Richmond, VA
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: October 2020 - September 2024
FY 2021 Funding Amount: $206,800
Total Award Amount
(all years):
$701,800
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

This Collaborative VA Merit Application (CMA) leverages expertise of accomplished researchers who formed a VA Colorectal Cancer (CRC) Cell-Genomics Consortium (VA4C) in May 2017. Cancer stem cells (CSCs) are critical mediators of carcinogenesis and induce cancer relapse resulting in poor outcomes. Glycosaminoglycans (GAGs), linear polysaccharides, that play a critical role in regulation of several hallmarks of cancer, engage various cell surface receptor targets, especially on CSCs. Yet, their b...



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