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Funded Project Details - FY2021

Project Number:

Title: The Orexin System as a Target for PTSD and Comorbid Psychosis
Principal Investigator:

Daniel J Lodge

Location: San Antonio, TX
Congressional District Code: 21
Research Service: Biomedical Laboratory R&D
Project Period: April 2020 - March 2024
FY 2021 Funding Amount: $264,290
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Project Summary/Abstract: Psychotic symptoms are highly prevalent in PTSD patients and are typically treated with dopamine D2 receptor antagonists; however, these drugs are associated with significant adverse effects. We have novel preliminary data demonstrating that the paraventricular nucleus of the thalamus (PVT) regulates dopamine neuron activity. We posit that the PVT therefore represents a potential therapeutic target for the treatment of PTSD as well as comorbid psychosis. The PVT receive...

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