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Funded Project Details - FY2021

Project Number:

Title: Control of Circuit Hyperexcitability by Endogenous Opioids in Epilepsy
Principal Investigator:

Eric Schnell

Location: Portland, OR
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: April 2020 - March 2024
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Epilepsy is a devastating neurologic condition that affects about 2 million Americans and is often resistant to medical treatment. Animal studies have demonstrated that epilepsy is associated with compensatory changes in the brain, which includes the aberrant rewiring of neuronal circuits. In particular, epilepsy is associated with altered connectivity in the hippocampus, a region of the brain that is frequently the focal point for the initiation of seizures. One particular hippocampal circuit r...

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