Funded Project Details - FY2021
|Title:|| Melanoma Resistance to Apoptosis: Mechanisms and Therapeutic Potential|
David A. Norris
|Congressional District Code:
||Biomedical Laboratory R&D
|| July 2020 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
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The incidence of melanoma is increasing rapidly in the VA population in the United States, and sun exposure during US military service has been linked to increased melanoma incidence. The standard of care for advanced melanomas includes molecular-targeted therapies of BRAF and MEK inhibitors, as well as immunotherapies with checkpoint inhibitors such as anti-PD1. However, between 25% to 70% of advanced melanoma patients either do not respond or relapse from the current treatments. Therefore, dis...
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