Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government

Office of Research & Development

print icon sign up for VA Research updates

Funded Project Details - FY2021




Project Number:

I01BX004935-01
Title: Restoring the Regulation of a Central Signaling Pathway to Prevent Metastases and Reinstate Tumor Immunity
Principal Investigator:

Eduardo Davila

Location: Denver, CO
Congressional District Code: 6
Research Service: Biomedical Laboratory R&D
Project Period: April 2020 - March 2024
FY 2021 Funding Amount: $270,571
Total Award Amount
(all years):
$1,275,115
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Our long-term goals are to understand the mechanisms by which IL-1 receptor associated kinase-M (IRAK- M) expression in melanoma regulates metastasis and to develop clinically-relevant approaches to induce and sustain anti-tumor T cell immunity by restoring IRAK-M expression. Cancer metastasis is the main cause of cancer mortality and morbidity, accounting for 90% of cancer-related deaths. Immunotherapy has revolutionized the treatment of advanced (metastatic) melanoma and is now the standard of...



Questions about the R&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.