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Funded Project Details - FY2021

Project Number:

Title: Restoring the Regulation of a Central Signaling Pathway to Prevent Metastases and Reinstate Tumor Immunity
Principal Investigator:

Eduardo Davila

Location: Denver, CO
Congressional District Code: 6
Research Service: Biomedical Laboratory R&D
Project Period: April 2020 - March 2024
FY 2021 Funding Amount: $270,571
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Our long-term goals are to understand the mechanisms by which IL-1 receptor associated kinase-M (IRAK- M) expression in melanoma regulates metastasis and to develop clinically-relevant approaches to induce and sustain anti-tumor T cell immunity by restoring IRAK-M expression. Cancer metastasis is the main cause of cancer mortality and morbidity, accounting for 90% of cancer-related deaths. Immunotherapy has revolutionized the treatment of advanced (metastatic) melanoma and is now the standard of...

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