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Funded Project Details - FY2021

Project Number:

Title: Pathogenic Tau Promotes Brain Vascular Dysfunction in Alzheimer's Disease
Principal Investigator:

Veronica Galvan

Location: San Antonio, TX
Congressional District Code: 21
Research Service: Biomedical Laboratory R&D
Project Period: January 2020 - December 2023
FY 2021 Funding Amount: $237,347
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The  coupling  of  neural  activity  and  increased  blood  flow  (neurovascular  coupling)  is  vital  to  brain  function.   Failure  of  this  coupling  occurs  early  in  Alzheimer’s  disease  (AD)  and  ‘pure’  tauopathies  and  induces  chronic  brain  injury,  contributing  to  neurodegeneration. Among other mediators, neurovascular coupling is regulated by  nitric  oxide  (NO)  bioavailability.  NO  formed  by  the  neuronal  form  of  nitric  oxide  synthase  (nNOS)  is  central  to  ne...

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