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Project Number: | I01BX002211-05A1 |
| Title: | Pathogenic Tau Promotes Brain Vascular Dysfunction in Alzheimer's Disease |
| Principal Investigator: | Veronica Galvan |
| Location: | San Antonio, TX |
| Congressional District Code: | 21 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2020 - December 2023 |
| FY 2021 Funding Amount: | $237,347 |
| Total Award Amount (all years): |
$1,120,079 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: The coupling of neural activity and increased blood flow (neurovascular coupling) is vital to brain function. Failure of this coupling occurs early in Alzheimer’s disease (AD) and ‘pure’ tauopathies and induces chronic brain injury, contributing to neurodegeneration. Among other mediators, neurovascular coupling is regulated by nitric oxide (NO) bioavailability. NO formed by the neuronal form of nitric oxide synthase (nNOS) is central to ne... |