Funded Project Details - FY2021
|Title:|| Pathogenic Tau Promotes Brain Vascular Dysfunction in Alzheimer's Disease|
||San Antonio, TX
|Congressional District Code:
||Biomedical Laboratory R&D
|| January 2020 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER
The coupling of neural activity and increased blood flow (neurovascular coupling) is vital to brain function. Failure of this coupling occurs early in Alzheimer’s disease (AD) and ‘pure’ tauopathies and induces chronic brain injury, contributing to neurodegeneration. Among other mediators, neurovascular coupling is regulated by nitric oxide (NO) bioavailability. NO formed by the neuronal form of nitric oxide synthase (nNOS) is central to ne...
Questions about the R&D website? Email the Web Team
Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.