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Project Number: | I01BX000669-09A1 |
| Title: | A Ribozyme Rescue Strategy for Dry Age-Related Macular Degeneration |
| Principal Investigator: | John M. Sullivan |
| Location: | Buffalo, NY |
| Congressional District Code: | 26 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2020 - December 2023 |
| FY 2021 Funding Amount: | $136,800 |
| Total Award Amount (all years): |
$810,000 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: In common dry age-related macular degeneration (dAMD) and orphan juvenile macular degeneration (JMD) (e.g., Stargardt) cellular and biochemical debris accumulates within and beneath the retinal pigment epithelium (RPE). These diseases reflect naturally occurring circadian shedding of rod and cone photoreceptor (PR) outer segment tips, and phagocytosis and lysosomal digestion by RPE cells. In the human parafovea, where dAMD and JMD starts, a single RPE cell underlies and supports about 30-35 rods... |