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Funded Project Details - FY2021

Project Number:

Title: SUMOylation of Cu transport protein Atox1 in Atherosclerosis
Principal Investigator:

Tohru Fukai

Location: Augusta, GA
Congressional District Code: 10
Research Service: Biomedical Laboratory R&D
Project Period: April 2020 - March 2024
FY 2021 Funding Amount: $244,608
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The aim of this grant is to demonstrate a novel redox-dependent SUMOylation of Copper (Cu) chaperone “Antioxidant-1 (Atox1)” as a key switch to promote Cu-dependent transcription factor function linked to vascular inflammation and atherosclerosis. Cu is implicated in inflammation and atherosclerosis with unknown mechanism. We previously found that Cu-chaperone Atox1 functions as a Cu-dependent transcription factor for p47phox to promote reactive oxygen species (ROS)-dependent inflammatory respon...

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