SUMOylation of Cu transport protein Atox1 in Atherosclerosis
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Biomedical Laboratory R&D
April 2020 -
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View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
The aim of this grant is to demonstrate a novel redox-dependent SUMOylation of Copper (Cu) chaperone “Antioxidant-1 (Atox1)” as a key switch to promote Cu-dependent transcription factor function linked to vascular inflammation and atherosclerosis. Cu is implicated in inflammation and atherosclerosis with unknown mechanism. We previously found that Cu-chaperone Atox1 functions as a Cu-dependent transcription factor for p47phox to promote reactive oxygen species (ROS)-dependent inflammatory respon...