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Funded Project Details - FY2021

Project Number:

Title: Enteroendocrine cell reprogramming during intestinal injury
Principal Investigator:

Brian Muegge

Location: St Louis, MO
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: February 2020 - January 2025
FY 2021 Funding Amount: $148,084
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


RESEARCH STRATEGY: The primary research objective of this proposal is to address how subtypes of enteroendocrine cells change their activity (secretion) or state of differentiation in response to injury signals. A better understanding of intestinal injury repair is critical to VA health priorities; the prevalence of inflammatory bowel disease (IBD) has more than doubled among VA patients since 1998 and at least half of patients won’t experience full mucosal healing with existing therapies. Hormo...

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