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Funded Project Details - FY2021

Project Number:

Title: Using CRISPR-Cas9 genetic abscission in vivo to study the role of GABA-A receptors of the thalamic reticular nucleus in regulating non-rapid-eye-movement sleep and drug induced sleep
Principal Investigator:

David Uygun

Location: Boston, MA
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: January 2020 - December 2024
FY 2021 Funding Amount: $210,941
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


This basic research proposal in mice dissects the neural circuitry and receptors that underlie therapeutic vs side effects of the sleep medicines used to treat Veterans, using a state-of-the-art gene editing approach called clustered regularly interspaced short palindromic repeats (CRISPR). The support of this CDA2 award would allow the applicant to be trained in in vivo reverse microdialysis and in vitro electrophysiology to allow him to comprehensively validate his genetic manipulations and di...

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