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Funded Project Details - FY2021




Project Number:

I01BX004861-01
Title: Validation of Premature Ventricular Contraction-induced Cardiomyopathy on a Swine Model
Principal Investigator:

Jose Huizar

Location: Richmond, VA
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: July 2020 - June 2024
FY 2021 Funding Amount: $398,407
Total Award Amount
(all years):
$1,704,472
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Background. Frequent premature ventricular contractions (PVCs) can cause LV dysfunction or cardiomyopathy (CM), referred to as PVC-cardiomyopathy (PVC-CM). The mechanism responsible this CM is unclear. A PVC—CM canine model was key not only to prove that PVC-CM can be induced in a normal structural heart, but also to identify preliminary cellular and molecular features that may explain the development of LV dysfunction. Until recently an alternative PVC-Cardiomyopathy model has been described in...



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