Validation of Premature Ventricular Contraction-induced Cardiomyopathy on a Swine Model
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Biomedical Laboratory R&D
July 2020 -
FY 2021 Funding Amount:
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View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Background. Frequent premature ventricular contractions (PVCs) can cause LV dysfunction or cardiomyopathy (CM), referred to as PVC-cardiomyopathy (PVC-CM). The mechanism responsible this CM is unclear. A PVC—CM canine model was key not only to prove that PVC-CM can be induced in a normal structural heart, but also to identify preliminary cellular and molecular features that may explain the development of LV dysfunction. Until recently an alternative PVC-Cardiomyopathy model has been described in...