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Funded Project Details - FY2021

Project Number:

Title: BLRD Research Career Scientist Award Application
Principal Investigator:

Robert J. Shmookler Reis

Location: Little Rock, AR
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: October 2019 - September 2026
FY 2021 Funding Amount: $213,184
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Protein aggregation underlies most or all types of neurodegeneration and many other age-progressive diseases. We have isolated and analyzed very pure aggregates from Alzheimer’s Disease (AD), Parkinson’s Disease (PD); nematode models of Huntington’s Disease (HD), AD, and PD; and human cell-culture models of AD. The proteins that contribute to these aggregates show considerable overlap; for example, >80% of proteins that are significantly more abundant in aggregates from AD than from age-matched...

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