Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government
ORD only    All VA Research websites

Office of Research & Development

print icon sign up for VA Research updates

Funded Project Details - FY2021

Project Number:

Title: Traumatic Brain Injury and Endogenous Pain Modulation
Principal Investigator:

David J. Clark

Location: Palo Alto, CA
Congressional District Code: 18
Research Service: Rehabilitation R&D
Project Period: April 2020 - March 2026
FY 2021 Funding Amount: $80,208
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Chronic pain and disability after war-related injuries and after trauma sustained in civilian settings are unexpectedly common. Chronic pain related to traumatic brain injury (TBI) in combination with peripheral injuries is particularly problematic, and we have no well-validated treatments. Potentially explaining the TBI- chronic pain relationship, data from both humans and animal models suggest that descending pain modulation is disrupted after TBI. Recently collected data using laboratory mode...

Questions about the R&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.