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Funded Project Details - FY2021




Project Number:

IK2RX003268-01A1
Title: Influence of aromatase on neuromuscular plasticity resulting from testosterone plus locomotor training after spinal cord injury
Principal Investigator:

Dana Otzel

Location: Gainesville, FL
Congressional District Code: 3
Research Service: Rehabilitation R&D
Project Period: April 2020 - March 2025
FY 2021 Funding Amount: $142,984
Total Award Amount
(all years):
$1,071,308
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

The motor dysfunction resulting from spinal cord injury (SCI) is precipitated by the neural insult and is exacerbated by other factors that hinder motoneuron survival and muscle recovery, including disuse and low testosterone (T). The success of bodyweight-supported treadmill training (BWSTT) diminishes as the SCI severity worsens. We have developed a novel strategy involving BWSTT with adjuvant T-enanthate (TE) drug treatment that promotes use-dependent neuroplasticity, in-part, by preserving w...



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