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Project Number: | I01RX002813-01A2 |
| Title: | Maximizing Hearing Recovery from Peri-Synaptic Damage |
| Principal Investigator: | Hongzhe LI |
| Location: | Loma Linda, CA |
| Congressional District Code: | 31 |
| Research Service: | Rehabilitation R&D |
| Project Period: | February 2020 - January 2024 |
| FY 2021 Funding Amount: | $294,538 |
| Total Award Amount (all years): |
$1,182,289 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Principal Investigator: Hongzhe Li Program Summary Project Title: Maximizing hearing recovery from peri-synaptic damage Program Summary Ototoxicants such as aminoglycoside antibiotics, and anti-neoplastic cisplatin, cause cytoplasmic stress within the sensory hair cells and the spiral ganglion neurons, affecting synaptic functionalities and signal transmission towards the central auditory system. We hypothesize that ototoxic cochlear synaptic damage that to some extent resembles noise-induced s... |