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Project Number: | I01BX004680-01A1 |
| Title: | Divergent roles of Slingshot-1 in tauopathy |
| Principal Investigator: | David Kang |
| Location: | Tampa, FL |
| Congressional District Code: | 14 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2020 - September 2024 |
| FY 2021 Funding Amount: | $311,824 |
| Total Award Amount (all years): |
$1,235,962 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Accumulation of toxic proteins (i.e. Aβ42 & tau) and dysfunctional mitochondria are associated with synaptic and neuronal loss in multiple neurodegenerative disorders, including Alzheimer’s disease (AD). Such clearance defects are thought to arise in large part from deficits in the autophagy-lysosome system. While mounting experimental evidence supports the notion that AD is a tauopathy at least in part driven Aβ, there is still a considerable knowledge gap in the way Aβ and tau pathogenesis are... |