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Funded Project Details - FY2021

Project Number:

Title: Role of Protein S in early Diabetic Kidney Disease
Principal Investigator:

John Cijiang He

Location: Bronx, NY
Congressional District Code: 13
Research Service: Biomedical Laboratory R&D
Project Period: October 2020 - September 2024
FY 2021 Funding Amount: $156,780
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Abstract: Glomerular disease such as diabetic kidney disease (DKD) and focal segmental glomerulosclerosis (FSGS) are the leading causes of end-stage renal disease. The treatment options of both diseased are very limited. Through proteomic analysis of glomeruli in diabetic rats, we identified protein S (PS) as a highly regulated protein in early DKD. PS is known to bind to TAM receptors (Tyro3, Axl, and Mer), which belong to a family of receptor tyrosine kinases that mediates regulation of inflam...

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