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Funded Project Details - FY2021

Project Number:

Title: Pathologic Signaling Pathways in AML Cells
Principal Investigator:

Martin Carroll

Location: Philadelphia, PA
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: January 2021 - December 2024
FY 2021 Funding Amount: $105,368
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Abstract: Acute myeloid leukemia (AML) is a serious blood cancer that affects United States Veterans and other individuals. Multiple studies have demonstrated that active signaling pathways are a necessary step to leukemic cell transformation. However, the mechanism(s) of activated signaling in FLT3 wild type AML are poorly described. We hypothesize that constitutive activation of the PI3 kinase pathway leads to activation of a complex called mammalian target of rapamycin 2 (mTORC2) which regula...

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