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Project Number: | I01BX004646-01A2 |
| Title: | Mechanisms contributing to co-morbid psychosis in Alzheimer's disease |
| Principal Investigator: | Daniel J Lodge |
| Location: | San Antonio, TX |
| Congressional District Code: | 21 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2020 - September 2024 |
| FY 2021 Funding Amount: | $248,817 |
| Total Award Amount (all years): |
$927,765 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Project Summary/Abstract: Psychotic symptoms (hallucinations and delusions) are highly prevalent Alzheimer's disease. Unfortunately, the antipsychotic medications used to treat psychosis are contraindicated in the elderly where the Food and Drug Administration (FDA) issued a black-box warning for all first- and second-generation antipsychotic medications indicating that these drugs increase the risk of death in elderly dementia patients. We have demonstrated that the hippocampus plays a central... |