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Funded Project Details - FY2021

Project Number:

Title: Genome engineering of stem cells for kidney regeneration
Principal Investigator:

Lauren E Woodard

Location: Nashville, TN
Congressional District Code: 5
Research Service: Biomedical Laboratory R&D
Project Period: April 2020 - March 2024
FY 2021 Funding Amount: $339,269
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


We propose to develop a regenerative gene and cell therapy treatment for acute kidney injury and/or chronic kidney disease. These studies are based on recent advances in isolation of adult stem cells from the urine. Urine-derived stem cells have several remarkable properties: they are easy to obtain, propagate for many passages, are multipotent, and home to sites of injury. We propose to genome modify urine-derived stem cells and track their homing in three mouse models of kidney injury (ischemi...

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