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Project Number: | I01BX004899-01A1 |
| Title: | Dynamic regulation of axonal trafficking and surface distribution of Nav1.7 in sensory neurons |
| Principal Investigator: | Stephen G. Waxman |
| Location: | West Haven, CT |
| Congressional District Code: | 3 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2021 - March 2025 |
| FY 2021 Funding Amount: | $126,568 |
| Total Award Amount (all years): |
$703,053 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Chronic pain is common among Veterans and remains an unmet medical need. Voltage-gated sodium channels (NaVs) that are expressed preferentially in primary afferents play a critical role in human pain disorders, and present opportune targets for the development of novel pain treatments that carry minimal CNS side effects and addictive potential. NaV1.7 is a peripheral threshold channel that regulates action potential firing and neurotransmitter release. Our work for the past 15 years has linked N... |