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Funded Project Details - FY2021




Project Number:

I01BX004899-01A1
Title: Dynamic regulation of axonal trafficking and surface distribution of Nav1.7 in sensory neurons
Principal Investigator:

Stephen G. Waxman

Location: West Haven, CT
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: April 2021 - March 2025
FY 2021 Funding Amount: $126,568
Total Award Amount
(all years):
$703,053
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Chronic pain is common among Veterans and remains an unmet medical need. Voltage-gated sodium channels (NaVs) that are expressed preferentially in primary afferents play a critical role in human pain disorders, and present opportune targets for the development of novel pain treatments that carry minimal CNS side effects and addictive potential. NaV1.7 is a peripheral threshold channel that regulates action potential firing and neurotransmitter release. Our work for the past 15 years has linked N...



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