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Project Number: | I01BX000926-09 |
| Title: | Mechanisms of Renal Cell Injury |
| Principal Investigator: | Goutam Ghosh-Choudhury |
| Location: | San Antonio, TX |
| Congressional District Code: | 21 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2021 - December 2024 |
| FY 2021 Funding Amount: | $167,600 |
| Total Award Amount (all years): |
$1,298,754 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Pathologic manifestations of diabetic nephropathy (DN) include glomerular and tubular hypertrophy and matrix protein fibronectin expression. These changes occur concomitant with increased expression of TGFb (transforming growth factor-b) that contributes to the pathogenesis of human and experimental DN. We interrogate the molecular signaling events by which high glucose and TGFb drive the pathologies and provide new potential therapeutic strategies for complications of DN. We have reported that... |