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Funded Project Details - FY2021




Project Number:

I01BX000926-09
Title: Mechanisms of Renal Cell Injury
Principal Investigator:

Goutam Ghosh-Choudhury

Location: San Antonio, TX
Congressional District Code: 21
Research Service: Biomedical Laboratory R&D
Project Period: January 2021 - December 2024
FY 2021 Funding Amount: $167,600
Total Award Amount
(all years):
$1,298,754
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Pathologic manifestations of diabetic nephropathy (DN) include glomerular and tubular hypertrophy and matrix protein fibronectin expression. These changes occur concomitant with increased expression of TGFb (transforming growth factor-b) that contributes to the pathogenesis of human and experimental DN. We interrogate the molecular signaling events by which high glucose and TGFb drive the pathologies and provide new potential therapeutic strategies for complications of DN. We have reported that...



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