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Project Number: | I01BX004167-01A2 |
| Title: | mTOR-Mediated Desaturation of Fatty Acids in Hepatic Insulin Resistance. |
| Principal Investigator: | Adam Salmon |
| Location: | San Antonio, TX |
| Congressional District Code: | 21 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2021 - December 2024 |
| FY 2021 Funding Amount: | $229,073 |
| Total Award Amount (all years): |
$1,129,772 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Discharged members of the US Armed Services are at an increased risk of metabolic disease which is exemplified by the prevalence of type 2 diabetes mellitus (T2DM) affecting an estimated 1/3 of all VHA patients. A key defect in the etiology of T2DM is the inability of insulin to suppress hepatic glucose production, or hepatic insulin resistance. Alterations in hepatic lipid metabolism precede hepatic insulin resistance and are regulated largely by mitochondrial fatty acid oxidation (β-oxidation)... |