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Funded Project Details - FY2021




Project Number:

I01BX004167-01A2
Title: mTOR-Mediated Desaturation of Fatty Acids in Hepatic Insulin Resistance.
Principal Investigator:

Adam Salmon

Location: San Antonio, TX
Congressional District Code: 21
Research Service: Biomedical Laboratory R&D
Project Period: January 2021 - December 2024
FY 2021 Funding Amount: $229,073
Total Award Amount
(all years):
$1,129,772
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Discharged members of the US Armed Services are at an increased risk of metabolic disease which is exemplified by the prevalence of type 2 diabetes mellitus (T2DM) affecting an estimated 1/3 of all VHA patients. A key defect in the etiology of T2DM is the inability of insulin to suppress hepatic glucose production, or hepatic insulin resistance. Alterations in hepatic lipid metabolism precede hepatic insulin resistance and are regulated largely by mitochondrial fatty acid oxidation (β-oxidation)...



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