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Funded Project Details - FY2021

Project Number:

Title: Rational Combination of MAP4K4 Inhibition and Immunotherapy in Pancreatic Cancer
Principal Investigator:

Ajay Rana

Location: Chicago, IL
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: October 2020 - September 2024
FY 2021 Funding Amount: $206,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Summary/Abstract: Pancreatic Ductal Adenocarcinoma (PDAC) remains remarkably lethal with a 5-year survival rate of less than 9%. Due to its widespread resistance to conventional therapy, PDAC is expected to be the second most common cause of cancer-related death in the United States by 2030. Oncogenic KRAS mutations are nearly uniform in PDAC, affecting over 90% of patients. The mutant KRAS is a key driver in the neoplastic phenotype, and leads to hyper-activation of KRAS, permitting for sustain...

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