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Project Number: | I01BX005117-01 |
| Title: | Hedgehog-Induced Activation of Alloimmune T Cells During Ischemia Reperfusion Injury |
| Principal Investigator: | Dan Jane-Wit |
| Location: | West Haven, CT |
| Congressional District Code: | 3 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2020 - September 2024 |
| FY 2021 Funding Amount: | $190,200 |
| Total Award Amount (all years): |
$693,400 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Ischemia reperfusion injury (IRI) is a pathological process affecting solid organ allografts and occurs when a transplanted organ subjected to prolonged disruption of blood flow undergoes tissue damage following surgical implantation. IRI frequently occurs among deceased donors and predisposes to chronic antibody- mediated rejection (CABMR), decreased graft survival, and worsened patient outcomes. This condition has no effective medical treatments and is especially relevant to veteran transplant... |