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Funded Project Details - FY2021




Project Number:

I01BX005117-01
Title: Hedgehog-Induced Activation of Alloimmune T Cells During Ischemia Reperfusion Injury
Principal Investigator:

Dan Jane-Wit

Location: West Haven, CT
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: October 2020 - September 2024
FY 2021 Funding Amount: $190,200
Total Award Amount
(all years):
$693,400
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Ischemia reperfusion injury (IRI) is a pathological process affecting solid organ allografts and occurs when a transplanted organ subjected to prolonged disruption of blood flow undergoes tissue damage following surgical implantation. IRI frequently occurs among deceased donors and predisposes to chronic antibody- mediated rejection (CABMR), decreased graft survival, and worsened patient outcomes. This condition has no effective medical treatments and is especially relevant to veteran transplant...



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