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Funded Project Details - FY2021

Project Number:

Title: Downregulation of Inflamm-aging for Protection Against Organ Damage in Sepsis
Principal Investigator:

Xianzhong Meng

Location: Denver, CO
Congressional District Code: 6
Research Service: Biomedical Laboratory R&D
Project Period: July 2021 - June 2025
FY 2021 Funding Amount: $111,276
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Older adults make a large proportion of sepsis patients. Organ dysfunction is common in patients with severe sepsis, and old septic patients often have more severe organ injury and longer-lasting organ dysfunction. However, the mechanism underlying exacerbated organ injury/dysfunction in old septic patients remain unclear. This proposal tests the central hypothesis that aging enhances and prolongs inflammation to exacerbate organ injury and to impede the recovery of organ function following seps...

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