Downregulation of Inflamm-aging for Protection Against Organ Damage in Sepsis
Congressional District Code:
Biomedical Laboratory R&D
July 2021 -
FY 2021 Funding Amount:
Total Award Amount (all years):
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Older adults make a large proportion of sepsis patients. Organ dysfunction is common in patients with severe sepsis, and old septic patients often have more severe organ injury and longer-lasting organ dysfunction. However, the mechanism underlying exacerbated organ injury/dysfunction in old septic patients remain unclear. This proposal tests the central hypothesis that aging enhances and prolongs inflammation to exacerbate organ injury and to impede the recovery of organ function following seps...