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Funded Project Details - FY2021




Project Number:

I01BX003324-05
Title: Targeting the Metabolome in Androgen Receptor-driven Castration-resistant Prostate Cancer
Principal Investigator:

Stephen R. Plymate

Location: Seattle, WA
Congressional District Code: 9
Research Service: Biomedical Laboratory R&D
Project Period: April 2020 - March 2024
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
$703,118
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Alterations in metabolism especially lipogenesis are unique to prostate cancer progression and the changes from benign to malignant prostate epithelium involves a switch from mitochondrial oxidative metabolism to generate energy needs for cellular processes to aerobic glycolysis in cancer cells. This process is critical for cell proliferation and new cell membrane synthesis including the continued proliferation driven by the androgen receptor in most castration resistant prostate cancers (CRPC)....



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