Funded Project Details - FY2021
|Title:|| Thrombin Cleavage of Osteopontin Suppresses Host-Anti-Tumor Immune Response in Cancer|
Lawrence L. Leung
||Palo Alto, CA
|Congressional District Code:
||Biomedical Laboratory R&D
|| July 2020 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
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Expression of osteopontin (OPN), a circulating matricellular protein with pleiotropic functions, is up-regulated in inflammation and cancer. OPN has multiple functional domains and a thrombin cleavage site (at Arg168 in human and Arg153 in mouse). Thrombin cleavage exposes a cryptic integrin-binding site for α4β1 and α9β1 integrins at the new C-terminus, SVVYGLR. We have shown that Arg168 is a bona fide thrombin cleavage site, and thrombin- cleaved OPN-Arg (OPN-R) has enhanced α4β1-dependent cel...
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