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Project Number: | I01BX005148-01 |
| Title: | Thrombin Cleavage of Osteopontin Suppresses Host-Anti-Tumor Immune Response in Cancer |
| Principal Investigator: | Lawrence L. Leung |
| Location: | Palo Alto, CA |
| Congressional District Code: | 18 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2020 - June 2024 |
| FY 2021 Funding Amount: | $141,800 |
| Total Award Amount (all years): |
$600,000 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Expression of osteopontin (OPN), a circulating matricellular protein with pleiotropic functions, is up-regulated in inflammation and cancer. OPN has multiple functional domains and a thrombin cleavage site (at Arg168 in human and Arg153 in mouse). Thrombin cleavage exposes a cryptic integrin-binding site for α4β1 and α9β1 integrins at the new C-terminus, SVVYGLR. We have shown that Arg168 is a bona fide thrombin cleavage site, and thrombin- cleaved OPN-Arg (OPN-R) has enhanced α4β1-dependent cel... |