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Funded Project Details - FY2021

Project Number:

Title: Thrombin Cleavage of Osteopontin Suppresses Host-Anti-Tumor Immune Response in Cancer
Principal Investigator:

Lawrence L. Leung

Location: Palo Alto, CA
Congressional District Code: 18
Research Service: Biomedical Laboratory R&D
Project Period: July 2020 - June 2024
FY 2021 Funding Amount: $141,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Expression of osteopontin (OPN), a circulating matricellular protein with pleiotropic functions, is up-regulated in inflammation and cancer. OPN has multiple functional domains and a thrombin cleavage site (at Arg168 in human and Arg153 in mouse). Thrombin cleavage exposes a cryptic integrin-binding site for α4β1 and α9β1 integrins at the new C-terminus, SVVYGLR. We have shown that Arg168 is a bona fide thrombin cleavage site, and thrombin- cleaved OPN-Arg (OPN-R) has enhanced α4β1-dependent cel...

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